Table 2.

Brain-regional MSR and COMT activities in diagnostic groups and COMT genotypes

		MSR			COMT			N
		PFC	STR	CER	PFC	STR	CER
Controls	Met/Met	66.9	53.65	97.48	12.19	11.44	33.15	1
	Met/Val	73.37 ± 4.63	88.24 ± 13.78	88.53 ± 8.09	19.29 ± 3.02	18.6 ± 2.72	34.39 ± 1.77	4
	Val/Val	86.05 ± 2.83	101.18 ± 0.94	122.42 ± 13	20.55 ± 6.3	17.8 ± 1.17	39.96 ± 21.19	4
Schizophrenia	Met/Met	75.83 ± 10.49	79.68 ± 15.95	92.81 ± 8.32	14.73 ± 3.19	13.12 ± 3.28	29.06 ± 1.98	4
	Met/Val	80.44 ± 4.04	99.41 ± 19.22	90.3 ± 10.79	19.56 ± 1.63	18.78 ± 2.01	32.07 ± 2.31	4
	Val/Val	93.27 ± 15.54	66.42 ± 5.57	85.95 ± 4.43	21.26 ± 2.16	18.11 ± 2.23	39.98 ± 5.85	2
Bipolar disorder	Met/Met	79.76 ± 7.11	96.86 ± 8.07	171.41 ± 20.1	26.93 ± 4.89	19.79 ± 5.58	65.02 ± 1.14	2
	Met/Val	74.98 ± 4.47	104.9 ± 7.33	143.37 ± 8.91	22.47 ± 3.18	31.54 ± 10.72	40.55 ± 6.01	9
	Val/Val	86.05 ± 2.83	101.18 ± 0.94	122.42 ± 13	20.55 ± 6.3	17.8 ± 1.17	39.96 ± 21.19	2

All values are means ± SEM. PFC, prefrontal cortex; STR, striatum, CER, cerebellum. COMT’s activity units: pmol HMBA / mg protein / min. Msr’s activity units: pmol dabsyl-Met / mg protein / min.