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. 2015 Jul 14;9:102. doi: 10.3389/fnsys.2015.00102

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Copyright © 2015 Ngwenya, Heyworth, Shwe, Moore and Rosene.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Capacity for neurogenesis declines with age. (A) The total number of Ki-67 positive nuclei significantly declines with age. Regression analysis predicts a 68% decline in Ki-67 positive cells between a 7 and a 25-years-old monkey (threefold change). (B) The total number of BrdU positive cell nuclei that are present after a 3-weeks survival also shows a significant negative correlation with age. Regression predicts a 53% decline between ages 7 and 25, which corresponds to a twofold change in BrdU labeled cells. (C) A photomicrograph illustrates BrdU immunohistochemistry with cresyl violet counterstain in the DG of a young monkey; scale bar = 100μm. The box represents a cluster of BrdU positive nuclei, which is enlarged in (D). (E) Aged animals also show clusters of BrdU positive nuclei as shown here. Scale bar for (D,E) = 20 μm.