Table 1.
Patient | Diagnosis | Sex | Age (years) | Months post DBS implantation | Years since onset of symptoms | Model/device | Unilateral/bilateral | Clinically set pulse duration (μs) | Clinically set frequency (Hz) | Clinically set amplitude | Randomized amplitude settings by patientc |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | ET | M | 72 | 4 | 18 | St Judes Brio ActiveTip 3 mm leadsa | Bilateral | 90 | 130 | 2.5 (bilateral) | 0.0, 0.75, 1.5, 2.2, 3.0, 3.5, 4.0 |
2 | ET | F | 48 | 17 | 20 | Medtronic activa RC model 3387b | Bilateral | 90 | 130 | 2.5 (bilateral) | 0.0, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5 |
3 | Cerebellar intention tremor | F | 71 | 15 | 35 | St Jude Libra ActiveTip 3 mm leadsa | Bilateral | 90 | 130 | 1.4 (L), 0.6 (R) | 0.0, 0.6, 1.5, 2.1, 2.8, 3.5, 4.2 |
4 | Dystonic tremor | F | 47 | 6 | 25 | Medtronic activa RC model 3387b | Bilateral | 90 | 130 | 3.5 (L), 2.3 (R) | 0.0, 1.5, 1.8, 2.1, 2.4, 2.7, 3.0 |
5 | ET | M | 56 | 16 | 18 | Medtronic activa RC model 3387b | Bilateral | 90 | 130 | 2.4 (L), 3.3 (R) | 3.3, 3.8, 4.4, 5.0, 5.4, 5.8d |
6 | ET | F | 44 | 15 | 30 | Medtronic activa RC model 3387b | Bilateral | 60 | 150 | 2.3 (bilateral) | 0.0, 1.5, 1.9, 2.4, 3.0, 3.6, 4.3 |
aDevice measured in milliamps.
bDevice measured in volts.
cPulse duration and frequency set to 90 and 130, respectively, for all patients and conditions.
dParticipant became emotionally labile when lower voltages were attempted.
ET, essential tremor; L, left; R, right; Hz, Hertz; mA, milliamps; M, male; F, female.
Patient 6 treated with clonazepam 0.5 mg/day in addition to DBS. All patients implanted bilaterally.