Table 5.
Optimal cut-off values of models in diagnosing significant liver fibrosis*
| Models | Cut-off values | Specificity (%) | Sensitivity (%) | Youden index† | NLR | PLR | NPV (%) | PPV (%) |
|---|---|---|---|---|---|---|---|---|
| LSM |
10.7 |
85.5 |
53.2 |
0.387 |
0.548 |
3.666 |
75.2 |
68.9 |
| S index |
0.1841 |
77.65 |
59.78 |
0.374 |
0.518 |
2.675 |
77.65 |
57.61 |
| GPRI | 0.2343 | 58.24 | 79.35 | 0.376 | 0.355 | 1.899 | 83.19 | 48.95 |
*APRI – aspartate transaminase (AST) to platelet (PLT) ratio index; FIB-4 – age-AST-PLT-alanine aminotransferase (ALT) index; GPRI – γ-glutamyl transpeptidase (GGT) to PLT ratio index; NLR – negative likelihood ratio; NPV – negative predictive value; PLR – positive likelihood ratio; PPV – positive predictive value; S index – GGT -PLT-albumin index.
†max (sensitivity + specificity −1).