Figure 1. This work focuses on analyzing robustness with respect to pairwise interactions.

Systems equipped with multiple signaling pathways can be framed in the context of robustness. Whereas previous work has shown dynamic entropy as a cancer “hallmark” through a nodal characterization, we expound upon this by providing a framework to analyzing gene-to-gene interaction robustness. In doing so, we will show that the method herein presents no “loss of information” and may be aptly suited to uncover particular pathways contributing to the robustness of cancer systems.