Table 1. Summary of proteomic changes in rd10 mice with or without Adalimumab.
Protein | C | rd10 | rd10 ADA | |
---|---|---|---|---|
OXPHOS | NDUFS3 | 3.1 ± 0.1 | 1.5 ± 0.2* | 2.4 ± 0.2a |
SDHB | 2.1 ± 0.1 | 1.3 ± 0.1* | 2.1 ± 0.2a | |
CORE2 | 1.4 ± 0.1 | 0.8 ± 0.1* | 1.3 ± 0.1a | |
COX II | 2.0 ± 0.1 | 0.9 ± 0.1* | 2.1 ± 0.2a | |
Β-F1 | 1.6 ± 0.1 | 0.9 ± 0.1* | 1.8 ± 0.1a | |
Glycolysis | GADPH | 2.0 ± 0.2 | 1.2 ± 0.1* | 2.1 ± 0.2a |
LDHA | 0.70 ± 0.02 | 0.34 ± 0.04* | 0.60 ± 0.05a | |
Pentose phosphate pathway | G6PDH | 0.48 ± 0.04 | 0.36 ± 0.05* | 0.64 ± 0.07a |
β-oxidation | HADHA | 0.34 ± 0.02 | 0.17 ± 0.01* | 0.37 ± 0.03a |
Mitochondrial dynamics | OPA1 | 1.9 ± 0.1 | 1.0 ± 0.1* | 1.8 ± 0.2a |
Mitochondrial structure | HSP60 | 0.13 ± 0.01 | 0.05 ± 0.01* | 0.14 ± 0.01a |
Note: Values are expressed as the mean ± SEM of fluorescence intensity (arbitrary units) per ng of total protein of six retinas per group. Values that are significantly different from C57Bl6 (C) are indicated by asterisks *p < 0.05. ‘a’ represent statistical differences (p < 0.05) between rd10 and rd10 ADA (One way ANOVA, Newman-Keuls post-test). ADA: Adalimumab.