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. 2015 Jul 14;5:12084. doi: 10.1038/srep12084

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Reagents and conditions: (a) 1-bromo-2-fluoroethane or 2-chloroethanol, KOH, EtOH, reflux; (b) 10% Pd/C, 1 atm H₂, 50 °C; (c) 1-(bromomethyl)-4-iodobenzene or 1-bromo-4-(bromomethyl)benzene, K₂CO₃, DMF, 90 °C; (d) TsCl, CH₂Cl₂, Et₃N, r.t.; (e) (Bu₃Sn)₂, (PPh₃)₄Pd, toluene, Et₃N, reflux; (f)¹⁸F^–, K₂CO₃, Kryptofix-2.2.2, acetonitrile, 100 °C; (g) [¹²⁵I]NaI, HCl (1 M), H₂O₂ (3%); (h) 1-bromo-2-fluoroethane or 1,2-dibromoethane, K₂CO₃, DMF, 90 ^oC; (i) NaBH₄, MeOH, 0 °C; (j) PBr₃, CH₂Cl₂, r.t.; (k) 4-iodophenol or 4-bromophenol, K₂CO₃, DMF, 90 °C; (l) AgOTs, MeCN, reflux.