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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Epigenomics. 2015;7(3):379–393. doi: 10.2217/epi.15.2

Figure 2. Lead causes common and gender-specific changes in DNA methylation.

Figure 2

The Pb-associated differentially methylated clusters (Pb-associated DMCs) selected for further analysis are screened by FDR cut off of 0.05 and effect size ≥∣0.02∣ or ∣2%∣ (A) A-clustering results for conserved region revealed 75 hyper-methylated Pb-associated DMCs and 41 hypo-methylated Pb-associated DMCs mapping to 76 unique genes associated with Pb exposure as predicted by the GEE model. (B) For an effect size cutoff of ∣0.02∣ or ∣2%∣, and FDR corrected P value ≤ 0.05, we found 94 Pb-associated hyper-methylated and Pb-associated 59 hypo-methylated regions mapping to 124 unique genes for males. (C) Analysis results for unique regions in females revealed 200 hyper-methylated and 74 hypo-methylated regions mapping to 201 unique genes.