Table 1.

Single nucleotide differences in DNA methylation between females and males as estimated by fixed effect model.

CpG site	Gene	Promoter associated	CpG island	Effect size	Standard error	P value	Holm.sig	FDR
cg22584138	SLC6A4	No	chr17:28562387- 28563186	0.074	0.012	3.91E-07	FALSE	0.001
cg04555966	GCK	No	chr7:44185961- 44186184	0.037	0.007	5.65E-06	FALSE	0.0089
cg09933329	GCK	No	chr7:44185961- 44186184	0.056	0.012	4.9E-05	FALSE	0.041
cg03314840	PKLR	No	chr1:155264318- 155265536	0.053	0.011	3.93E-05	FALSE	0.0357
cg12177922	HAX1	Yes	chr1:154244710- 154245289	0.052	0.007	1.06E-08	TRUE	5.44E-05
cg21763723	GPX1	Yes	chr3:49394855- 49395942	0.042	0.009	2.62E-05	FALSE	0.027
cg25187648	GPX1	Yes	chr3:49394855- 49395942	0.054	0.007	1.38E-08	TRUE	6.88E-05
cg11924019	CYP1A1	No	chr15:75018186- 75019336	0.053	0.011	5.6E-05	FALSE	0.0448
cg02891686	SOD3	No	chr4:24801109- 24801902	0.045	0.009	8.5E-06	FALSE	0.0123
cg11304734	POLR1E	Yes	chr9:37485801- 37486099	0.045	0.009	1.47E-05	FALSE	0.0182
cg14268223	DNAJA1	Yes	chr9:33025082- 33025797	−0.047	0.009	2.06E-05	FALSE	0.0237
cg13479204	HOXB3	No	chr17:46641534- 46642110	−0.082	0.016	1.2E-05	FALSE	0.0159
cg05323879	HOXB3	No	chr17:46641534- 46642110	0.476	−0.071	2.39E-05	FALSE	0.0257
cg02325951	FOXN3	No	chr14:89882421- 89884278	−0.062	0.007	9.55E-10	TRUE	7.23E-06
cg26355737	TFDP1	No	chr13:114292551- 114292886	−0.034	0.006	6.91E-07	FALSE	0.00174
cg19292611	TFDP1	N0	chr13:114292551- 114292886	−0.023	0.004	4.24E-06	FALSE	0.00726

For the analysis, the females where used as experimental group and males as the control group. All analysis was controlled for covariates such as age of the child, gestational age of the mother, age of the mother, smoking status of the household and blood lead levels.

FDR: False discovery rate; Holm: Holm–Bonferroni statistical method.