Figure 3. Level of chromatin repression does not affect drug synergy between a TNF and a pTEF-b inhibitor.
A-B) TNF dose response curves for (A) J-Lat 8.4 and (B) J-Lat 10.6 alone (gray line) and with 5mM HMBA (black line). GFP expression was measured by flow cytometry. Data are reported as the mean ± standard deviation of three biological replicates. C-D) Quantification of drug synergy between TNF and HMBA for (C) J-Lat 8.4 and (D) J-Lat 10.6 using the Bliss indepence model of drug interactions.