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. 2015 Jul 14;13:224. doi: 10.1186/s12967-015-0594-x

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© Backes et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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a Pileup plot for miR-1307. In case of miR-1307-5p, control patients show increased frequency of 1–2 base shifts at the 3p end. The pie diagram at the lower part of the figure shows that around one-third of all analyses revealed respective iso-forms. b Pileup plot for miR-3172. For miR-3127-3p, AD samples are frequently shifted by 1–2 bases to the 3p end of this miRNA. The pie chart as result of the aggregation analysis indicates that respective results are usually not observed. c Pileup plot for miR-378b. Extended mappings at the 3p end of this miRNA are almost exclusively observed for AD patients.