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. 2015 Jul 14;5:11827. doi: 10.1038/srep11827

Figure 1. Structures of previously disclosed antibacterial inhibitors of DNA gyrase/Topo IV.

Figure 1

The four compounds are representatives of four drug classes that operate by orthogonal modes-of-inhibition. ETX0914 is spiropyrimidinetrione with noteworthy activity versus Staphylococci and Streptococci and fastidious Gram-negative pathogens including N. gonorrhoeae. Ciprofloxacin 2 is one of dozens of fluoroquinolones that have been introduced into the clinic. NBTI 3 is a representative from an aminopiperidine class of agents with three reported compounds having progressed to human clinical trials, only one of which is known have progressed to patient trials. Novobiocin 4 is the only commercialized example of a broad class of DNA gyrase/Topo IV ATP competitive inhibitors.