Table 2. Clinical doses and associated fAUC/MIC PK/PD targets in the treatment of complicated skin infection and gonococcal infection.

Compound	Skin infection (S. aureus)			Gonococcal infection (N. gonorrhoeae)
	Clinical dose	MIC90 (μg/mL)	PK/PD magnitude	Clinical dose	MIC90 (μg/mL)	PK/PD magnitude
Ofloxacin	400 mg BID	2	28–40	400 mg UID	0.25–0.5	43–86
Ciprofloxacin	500–750 mg BID	1	19–44	250 mg UID 500 mg UID	0.06–0.12 0.25–0.5	28–56 19–38
ETX0914	800–1600 mg BID	0.25	66–139	800–1600 mg UID	0.12	66–139