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. Author manuscript; available in PMC: 2015 Jul 14.
Published in final edited form as: Nature. 2014 Jun 11;510(7505):407–411. doi: 10.1038/nature13444

Figure 2. Inactivation of p110δ in Treg is sufficient to confer cancer resistance.

Figure 2

a, Relative and total numbers of Treg in the draining lymph nodes of naive and 4T1 tumour-bearing mice. b, Impact of adoptive transfer of Treg into δD910A mice on EL4 tumour wet weight and tumour-infiltrating CD8+ T cells. c, Number of mice with visible B16 tumours and B16 tumour weight in mice of the indicated genotype. d, Survival of EL4 tumour-bearing mice of the indicated genotype. a-c, Statistically significant differences are indicated by * (P<0.05) or ** (P<0.01), as determined by the non-parametric Mann-Whitney t test or Anova. Between brackets: number of mice used per experiment. Each dot represents an individual mouse.