Table 2.
The differentially expressed metabolites between SZ and HC group
| Metabolites | Metabolic pathway | Training set | Test set | ||
|---|---|---|---|---|---|
| Log2(FC)a | P valueb | Log2(FC)a | P valueb | ||
| Glucose | Glycosis | 4.22 | 0.000 | 0.67 | 0.000 |
| Glucose 6-phosphate | Glycosis | 1.84 | 0.000 | 1.48 | 0.000 |
| Fructose 6-phosphate | Glycosis | 1.84 | 0.000 | 1.06 | 0.000 |
| Fructose | Glycosis | 6.12 | 0.000 | 0.48 | 0.003 |
| Glyceraldehyde-3-phosphate | Glycosis | −1.91 | 0.000 | −1.05 | 0.006 |
| Dihydroxyacetone phosphate | Glycosis | −2.28 | 0.000 | −1.28 | 0.000 |
| Glycerol 3-phosphate | Glycosis | −0.6 | 0.000 | −0.49 | 0.001 |
| Glycerate 3-phosphate | Glycosis | 0.88 | 0.000 | 0.28 | 0.363 |
| Pyruvate | Glycosis | 0.54 | 0.090 | 0.82 | 0.013 |
| Lactic acid | Glycosis | −0.11 | 1.000 | −0.79 | 0.002 |
| Citric acid | TCA | −1.08 | 0.000 | −0.71 | 0.001 |
| Succinic acid | TCA | 3.08 | 0.000 | 0.76 | 0.001 |
| Ribose 5-phosphate | Pentose phosphate pathway | 4.53 | 0.000 | −0.39 | 0.133 |
Values given in bold denote statistically significant results (P < 0.05).
SZ schizophrenia, HC healthy controls, FC fold change, TCA tricarboxylic acid cycle.
aA negative log2(FC) indicated significantly lower expression in schizophrenia subjects compared to healthy controls; a positive log2(FC) indicated significantly higher expression in schizophrenia subjects compared to healthy controls.
bThese data were analyzed using one-way ANOVA followed by Bonferroni post hoc test between two groups of each cohort.