Table 3.
The differentially expressed metabolites between MD and HC group
| Metabolites | Metabolic pathway | Training set | Test set | ||
|---|---|---|---|---|---|
| Log2(FC)a | P valueb | Log2(FC)a | P valueb | ||
| Glucose | Glycosis | 0.50 | 1.000 | 0.34 | 0.239 |
| Glucose 6-phosphate | Glycosis | 0.74 | 0.228 | 0.38 | 1.000 |
| Fructose 6-phosphate | Glycosis | 0.99 | 0.019 | 0.18 | 1.000 |
| Fructose | Glycosis | 0.08 | 1.000 | 0.29 | 0.198 |
| Glyceraldehyde-3-phosphate | Glycosis | −0.09 | 0.907 | −0.25 | 0.802 |
| Dihydroxyacetone phosphate | Glycosis | 0.71 | 0.000 | −0.79 | 0.004 |
| Glycerol 3-phosphate | Glycosis | −0.09 | 1.000 | −0.10 | 1.000 |
| Glycerate 3-phosphate | Glycosis | −0.71 | 0.190 | −0.28 | 0.692 |
| Pyruvate | Glycosis | 0.34 | 0.606 | 0.22 | 1.000 |
| Lactic acid | Glycosis | −0.15 | 1.000 | −0.31 | 0.239 |
| Citric acid | TCA | −0.09 | 1.000 | −0.11 | 1.000 |
| Succinic acid | TCA | 0.07 | 1.000 | 0.71 | 0.003 |
| Ribose 5-phosphate | Pentose phosphate pathway | −0.03 | 1.000 | −0.16 | 1.000 |
Values given in bold denote statistically significant results (P < 0.05).
MD major depression, HC healthy controls, FC fold change, TCA tricarboxylic acid cycle.
aA negative log2(FC) indicated significantly lower expression in major depressive subjects compared to healthy controls; a positive log2(FC) indicated significantly higher expression in major depressive subjects compared to healthy controls.
bThese data were analyzed using one-way ANOVA followed by Bonferroni post hoc test between two groups of each cohort.