Table 4.
The differentially expressed metabolites between SZ and MD group
| Metabolites | Metabolic pathway | Training set | Test set | ||
|---|---|---|---|---|---|
| Log2(FC)a | P valueb | Log2(FC)a | P valueb | ||
| Glucose | Glycosis | 3.73 | 0.000 | 0.32 | 0.071 |
| Glucose 6-phosphate | Glycosis | 1.09 | 0.000 | 1.10 | 0.000 |
| Fructose 6-phosphate | Glycosis | 0.85 | 0.000 | 0.88 | 0.001 |
| Fructose | Glycosis | 6.04 | 0.000 | 0.19 | 0.342 |
| Glyceraldehyde-3-phosphate | Glycosis | −1.83 | 0.000 | −0.80 | 0.114 |
| Dihydroxyacetone phosphate | Glycosis | −2.99 | 0.000 | −0.49 | 0.849 |
| Glycerol 3-phosphate | Glycosis | −0.52 | 0.000 | −0.39 | 0.020 |
| Glycerate 3-phosphate | Glycosis | 1.59 | 0.000 | 0.56 | 0.022 |
| Pyruvate | Glycosis | 0.2 | 1.000 | 0.60 | 0.057 |
| Lactic acid | Glycosis | 0.04 | 1.000 | −0.48 | 0.198 |
| Citric acid | TCA | −0.98 | 0.000 | −0.60 | 0.008 |
| Succinic acid | TCA | 3.01 | 0.000 | 0.06 | 1.000 |
| Ribose 5-phosphate | Pentose phosphate pathway | 4.56 | 0.000 | −0.23 | 0.820 |
Values given in bold denote statistically significant results (P < 0.05).
SZ schizophrenia, MD major depression, FC fold change, TCA tricarboxylic acid cycle.
aA negative log2(FC) indicated significantly lower expression in schizophrenia subjects compared to major depressive subjects; a positive log2(FC) indicated significantly higher expression in schizophrenia subjects compared to major depressive subjects.
bThese data were analyzed using one-way ANOVA followed by Bonferroni post hoc test between two groups of each cohort.