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Lifetime risks of ovarian cancer to a 20-year-old born in the 1940 birth cohort without a BRCA1 or BRCA2 mutation with different polygenic risk score (PRS) and family history. Graph of the change in probabilities of developing ovarian cancer by age 80 as PRS increases from −0.8 to 0.8, to a 20 year old with five different family histories. The two dotted lines, at −0.496 and 0.496, indicate the PRS of those at the 5th and 95th percentile of risk.
