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. 2015 May 29;52(7):465–475. doi: 10.1136/jmedgenet-2015-103077

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Proportion of cases accounted for by a given proportion of the population above a specified risk of ovarian cancer according to the total polygenic risk and the observed 17 SNP distribution. Under the total polygenic risk distribution, 50% of cancers occur in the 7.7% of the population at highest risk and 92.4% of cancers occur in the half of the population at greater-than-average risk, whereas under the 17 SNP only 62% of cancers occur in the 50% at higher risk and 50% of cases are spread among almost 40% of the population at highest risk.