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. 2015 Jul 14;9:244. doi: 10.3389/fnins.2015.00244

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Copyright © 2015 Haga-Yamanaka, Ma and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of VSN by E1050. (A,B) Examples of sigmoidal (A) and bell-shaped (B) dose-response curves to E1050. (C) Dose-response curves of individual cells (gray) and a sigmoidal curve (black) fitted to the average amplitude from all cells. Error bar, S.E.M. (D) Pie charts showing the number of cells exhibiting sigmoidal (S, blue), bell-shaped (B, red), and other (O, green) types of dose responses. Cells with FRC of 10⁻⁷ M are shown in gray. Concentration above each pie chart represents the first response concentration of the cells.