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. 2015 Jul 15;15:139. doi: 10.1186/s12866-015-0474-9

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© Chang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Serum cross-neutralization titers generated by seven EV-A71 vaccine candidates. Eight groups (n = 8 per group) of femal adult ICR mice were immunized with EV-A71 vaccine candidates including CC063, CC072, CC077, CC080, CC085, SHZH98, FY0805, and MEM (negative control) twice at 2 week intervals: a Diagram of the experimental procedure. b CC063 vaccine candidate produced highest mean cross-neutralization titers (GMT = 311). Mean cross-neutralization titers of the other EV-A71 strains were 100, 83, 111, 98, 113, and 117 (exclude CV-A16-CC024 and BrCr) for CC072, CC077, CC080, CC085, SHZH98 and FY0805, separately. The values for the negative control and CV-A16-CC024 sera were all < 8