Table 2.
Summary of the SNPs associated with high Yu-Zhi score in type 2 diabetes
| RA frequency | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dbSNP ID | Chr. | Position (Mb) | Gene | RA* (NRA) | High YZ score | Low YZ score | p-value‡ (Best model) | -log (p-value) | best model | Effect size (95 % CI) | FDR |
| rs12036718 | 1p | 48.3 | Unknow | T(C) | 0.174 | 0.103 | 8.10 × 10−6 | 5.09 | Trend | 1.68 (0.95 -2.99) | 1.00 |
| rs1932064 | 1p | 70.8 | Unknow | T(C) | 0.788 | 0.700 | 6.18 × 10−6 | 5.21 | Dominant | 1.62 (1.05 -2.51) | 0.97 |
| rs8179355 | 1p | 70.9 | Unknow | C(A) | 0.782 | 0.699 | 7.53 × 10−6 | 5.12 | Recessive | 1.54 (1.25 -1.89) | 0.86 |
| rs9633289 | 1p | 70.9 | Unknow | T(A) | 0.217 | 0.298 | 6.18 × 10−6 | 5.21 | Recessive | 1.55 (1.11 -2.15) | 0.95 |
| rs7565310 | 2q | 128.9 | Unknow | A(G) | 0.484 | 0.380 | 8.63 × 10−6 | 5.06 | Trend | 1.53 (1.27 -1.84) | 0.83 |
| rs7694118 | 4q | 134.3 | PCDH10 | C(T) | 0.698 | 0.663 | 6.31 × 10−6 | 5.20 | Genotype | 1.30 (0.85 -1.99) | 1.00 |
| rs164368 | 5q | 160.6 | Unknow | T(C) | 0.803 | 0.785 | 6.14 × 10−6 | 5.21 | Genotype | 1.12 (0.89 -1.40) | 1.00 |
| rs7493 | 7q | 94.9 | PON2 | C(G) | 0.180 | 0.177 | 5.33 × 10−6 | 5.27 | Genotype | 1.06 (0.74 -1.51) | 1.00 |
| rs2299263 | 7q | 94.9 | PON2 | A(G) | 0.180 | 0.177 | 5.33 × 10−6 | 5.27 | Genotype | 1.06 (0.74 -1.51) | 1.00 |
| rs17166875 | 7q | 94.9 | PON2 | T(C) | 0.180 | 0.177 | 5.33 × 10−6 | 5.27 | Genotype | 1.02 (0.81 -1.29) | 1.00 |
| rs12865228 | 13q | 38.2 | FREM2 | G(T) | 0.429 | 0.414 | 3.38 × 10−6 | 5.47 | Genotype | 1.06 (0.88 -1.28) | 1.00 |
| rs4526895 | 13q | 38.2 | FREM2 | C(T) | 0.428 | 0.414 | 1.79 × 10−6 | 5.75 | Genotype | 1.38 (0.93 -2.04) | 1.00 |
| rs17118382 | 14q | 82.8 | Unknow | A(G) | 0.815 | 0.730 | 9.75 × 10−6 | 5.01 | Allele | 1.45 (1.03 -2.04) | 0.98 |
| rs194045 | 16p | 29.2 | Unknow | G(A) | 0.943 | 0.888 | 6.31 × 10−6 | 5.20 | Trend | 2.13 (1.51 -3.02) | 0.83 |
| rs8093481 | 18p | 10.7 | PIEZO2 | A(G) | 0.757 | 0.656 | 9.64 × 10−7 | 6.02 | Trend | 1.79 (1.16 -2.77) | 0.93 |
| rs11660953 | 18p | 10.7 | PIEZO2 | T(C) | 0.756 | 0.656 | 1.60 × 10−6 | 5.79 | Trend | 1.79 (1.16 -2.77) | 0.93 |
| rs1133146 | 19q | 58.4 | ZNF665 | A(G) | 0.990 | 0.956 | 4.77 × 10−6 | 5.32 | Allele | 1.52 (1.01 -2.29) | 0.99 |
| rs12971799 | 19q | 58.4 | ZNF665 | C(T) | 0.700 | 0.599 | 4.77 × 10−6 | 5.32 | Allele | 1.49 (0.99 -2.25) | 1.00 |
| rs4801958 | 19q | 58.4 | ZNF665 | T(C) | 0.700 | 0.599 | 4.77 × 10−6 | 5.32 | Allele | 1.56 (1.29 -1.89) | 0.83 |
| rs12460170 | 19q | 58.4 | ZNF665 | G(A) | 0.699 | 0.600 | 7.56 × 10−6 | 5.12 | Allele | 1.56 (1.29 -1.89) | 0.83 |
| rs4803055 | 19q | 58.4 | ZNF665 | C(T) | 0.737 | 0.639 | 4.87 × 10−6 | 5.31 | Allele | 1.56 (1.02 -2.38) | 0.98 |
| rs871913 | 20p | 16.1 | Unknow | A(G) | 0.099 | 0.045 | 8.24 × 10−6 | 5.08 | Trend | 1.86 (0.78 -4.44) | 1.00 |