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. 2015 Jul 8;10:4405–4423. doi: 10.2147/IJN.S82818

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© 2015 Gandham et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Evaluation of HK2 inhibition by 3-BPA delivered into SKOV-3 ovarian cancer cell spheroids using aqueous solution and non-targeted and targeted liposomal formulations at 3, 6, and 24 hours after treatment.

Notes: The values are reported as the mean ± standard deviation for n=3. ^#HK2 activity levels were below the detection limits of the assay for the 100 µM samples. *P<0.01, **P<0.0001, Student’s t-test (unpaired and two-tailed).

Abbreviations: 3-BPA, 3-bromopyruvate; HK2, hexokinase-2; min, minutes.