Table 4.
Changes from baseline to Week 53 in mean eGFR and median A/Cr ratio
| Parameter | 0.2 mg/kg EOW | 0.2 mg/kg weekly | 0.4 mg/kg weekly | 0.2 mg/kg weekly minus EOW
|
||
|---|---|---|---|---|---|---|
| LSM difference | CI | P-value | ||||
| Mean eGFR, mL/min/1.73 m2 | ||||||
| BL (n) | 82.0 (20) | 78.1 (19) | 72.1 (5) | −1.56 | 95.005% CI: | Unadjusted |
| Wk 53 (n) | 78.3 (17) | 77.5 (18) | 70.4 (5) | −9.23, 6.12 | P=0.6830 | |
| Change | −1.21 | −3.32 | −1.68 | |||
| 95% CI | −7.46, 5.05 | −9.63, 2.99 | −14.00, 10.64 | |||
| SD | 34.1 | 33.8 | 31.2 | |||
| Mediana A/Cr ratio | ||||||
| BL (n) | 41.5 (20) | 40.0 (19) | 250.0 (5) | −134.91 | 95% CI: | P=0.4342 |
| Wk 53 (n) | 24.0 (17) | 27.0 (17) | 151.0 (5) | −482.22, 212.41 | ||
| Change | −7.0 | −6.0 | −64.0 | |||
| 95% CI | −237.3, 405.2 | −219.9, 111.8 | −420.3, 311.9 | |||
Notes: Change is calculated based on mean values. All CIs are calculated based on the mean (descriptive or least squares).
a
Median values used due to high variability of mean values.
Abbreviations: A/Cr, albumin creatinine ratio; BL, baseline; CI, confidence interval; eGFR, estimated glomerular filtration rate; EOW, every other week; LSM, least squares mean; SD, standard deviation; Wk, week.