Table 5.
CKD stage | 1A (n=3) | 1B (n=3) | 2 (n=10) | 3 (n=3) | 4/5 (n=1) |
---|---|---|---|---|---|
0.2 mg/kg EOW | |||||
Mean (SD) eGFR at BL, mL/min/1.73 m2 | 137.3 (9.6) | 108.3 (8.6) | 75.6 (6.8) | 46.3 (14.3) | 8.2 |
Mean (95% CI) change from BL | −24.2 (−82.6, 34.2) | 1.6 (−35.4, 38.7) | 4.5 (−1.2, 10.1) | −5.0 (−27.3, 17.2) | −1.2 (−7.5, 5.0) |
0.2 mg/kg weekly | (n=2) | (n=5) | (n=7) | (n=3) | (n=2) |
Mean (SD) eGFR at BL, mL/min/1.73 m2 | 142.5 (3.8) | 97.5 (7.1) | 74.7 (11.2) | 47.2 (15.3) | 23.4 (7.4) |
Mean (95% CI) change from BL | −24.4 (−71.4, 22.6) | −4.3 (−21.4, 12.8) | −1.2 (−8.4, 5.9) | 7.3 (−24.6, 39.2) | −2.9 |
0.4 mg/kg weekly | (n=0) | (n=1) | (n=3) | (n=0) | (n=1) |
Mean (SD) eGFR at BL, mL/min/1.73 m2 | 109.9 | 75.5 (6.9) | 23.9 | ||
Mean (95% CI) change from BL | −0.4 | −2.3 (−37.0, 32.4) | −1.0 |
Notes: CKD stage 1A: ≥130 mL/min/1.73 m2; 1B: 90 mL/min/1.73 m2 to <130 mL/min/1.73 m2; 2: 60 mL/min/1.73 m2 to <90 mL/min/1.73 m2; 3: 30 mL/min/1.73 m2 to <60 mL/min/1.73 m2; 4/5: 0 to <30 mL/min/1.73 m2. Change is calculated based on mean values. All CIs are calculated based on the mean (descriptive or least squares).
Abbreviations: BL, baseline; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; EOW, every other week; SD, standard deviation.