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. 2015 Jul 8;9:3435–3444. doi: 10.2147/DDDT.S80928

Table 5.

Estimated glomerular filtration rate by CKD stage: mean change from baseline by Week 53

CKD stage 1A (n=3) 1B (n=3) 2 (n=10) 3 (n=3) 4/5 (n=1)
0.2 mg/kg EOW
Mean (SD) eGFR at BL, mL/min/1.73 m2 137.3 (9.6) 108.3 (8.6) 75.6 (6.8) 46.3 (14.3) 8.2
Mean (95% CI) change from BL −24.2 (−82.6, 34.2) 1.6 (−35.4, 38.7) 4.5 (−1.2, 10.1) −5.0 (−27.3, 17.2) −1.2 (−7.5, 5.0)
0.2 mg/kg weekly (n=2) (n=5) (n=7) (n=3) (n=2)
Mean (SD) eGFR at BL, mL/min/1.73 m2 142.5 (3.8) 97.5 (7.1) 74.7 (11.2) 47.2 (15.3) 23.4 (7.4)
Mean (95% CI) change from BL −24.4 (−71.4, 22.6) −4.3 (−21.4, 12.8) −1.2 (−8.4, 5.9) 7.3 (−24.6, 39.2) −2.9
0.4 mg/kg weekly (n=0) (n=1) (n=3) (n=0) (n=1)
Mean (SD) eGFR at BL, mL/min/1.73 m2 109.9 75.5 (6.9) 23.9
Mean (95% CI) change from BL −0.4 −2.3 (−37.0, 32.4) −1.0

Notes: CKD stage 1A: ≥130 mL/min/1.73 m2; 1B: 90 mL/min/1.73 m2 to <130 mL/min/1.73 m2; 2: 60 mL/min/1.73 m2 to <90 mL/min/1.73 m2; 3: 30 mL/min/1.73 m2 to <60 mL/min/1.73 m2; 4/5: 0 to <30 mL/min/1.73 m2. Change is calculated based on mean values. All CIs are calculated based on the mean (descriptive or least squares).

Abbreviations: BL, baseline; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; EOW, every other week; SD, standard deviation.