Table 5.

List of the identified post-translational modification enzymes in the C. tribblei transcriptome

Post-translational modification enzymes	Function
protein disulfide isomerase (PDI) PDIA, PDI A3 (ERP57), A4 (ERP72), A5 (PDIR) and A6 (P5) families	disulfide bond formation
thioredoxin-related transmembrane protein 1 and 2 families, thioredoxin domain containing protein 5 and 12 families, 15 kDa selenoprotein and sulfhydryl oxidase 1	protein folding
hsp40 (DNAJ), Sacsin, hsp20, hsp70, hsp60, hsp90, hsp105, Grp78 (BiP), Calnexin, Calreticulin and T-complex protein 1	chaperone and co-chaperone in protein folding and disulfide bond formation
peptidylprolyl cis-trans isomerases (PPIases) cyclophilin and FKBP families	cis-trans isomerization of proline
Vitamin K dependent gamma-carboxylase Vitamin K epoxide reductase	conversion of glutamic acid to γ-carboxyglutamic acid
glutaminyl-peptide cyclotransferase	cyclization of N-terminal glutamine to pyroglutamatein
peptidyl-glycine alpha-amidating monooxygenase: peptidylglycine alpha-hydroxylating monooxygenamse (PHM) peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL)	alpha-amidation
cysteine-rich secretory protein (CRISP)	cleavage of the mature conopeptides from their propeptide precursors
conoporin	haemolytic activities
conohyal	degradation of extracellular matrix
metalloprotease, C-type lectin, serine protease and serine protease inhibitor	antihemostatic role