Table 5.
Post-translational modification enzymes | Function |
---|---|
protein disulfide isomerase (PDI)
|
disulfide bond formation |
thioredoxin-related transmembrane protein 1 and 2 families, thioredoxin domain containing protein 5 and 12 families, 15 kDa selenoprotein and sulfhydryl oxidase 1 | protein folding |
hsp40 (DNAJ), Sacsin, hsp20, hsp70, hsp60, hsp90, hsp105, Grp78 (BiP), Calnexin, Calreticulin and T-complex protein 1 | chaperone and co-chaperone in protein folding and disulfide bond formation |
peptidylprolyl cis-trans isomerases (PPIases)
|
cis-trans isomerization of proline |
Vitamin K dependent gamma-carboxylase Vitamin K epoxide reductase |
conversion of glutamic acid to γ-carboxyglutamic acid |
glutaminyl-peptide cyclotransferase | cyclization of N-terminal glutamine to pyroglutamatein |
peptidyl-glycine alpha-amidating monooxygenase:
|
alpha-amidation |
cysteine-rich secretory protein (CRISP) | cleavage of the mature conopeptides from their propeptide precursors |
conoporin | haemolytic activities |
conohyal | degradation of extracellular matrix |
metalloprotease, C-type lectin, serine protease and serine protease inhibitor | antihemostatic role |