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. Author manuscript; available in PMC: 2015 Jul 14.
Published in final edited form as: Nat Rev Neurosci. 2012 Feb 8;13(3):157–168. doi: 10.1038/nrn3168

Figure 1. Model of regenerative Ca2+ release and wave propagation.

Figure 1

a | Opening the inositol trisphosphate receptor (IP3R) requires both IP3 and Ca2+. The Ca2+ released through the receptor can act on the same IP3R or other IP3Rs to cause calcium-induced calcium release (CICR). b | By acting on other receptors, Ca2+ release can propagate as far as IP3 is available. The analogy to ‘toppling dominos’ (lower panel) is appropriate. Figure is adapted from REF. 138 © (2010) The Japan Academy.