Fig. 5.

Cigarette smoke extract inhibits NE and increases mucus accumulation. a Quantification of COPD mucin degradation after incubation at 37 °C with increasing concentrations of CSC (5–40 mg/mL) for 0, 24 and 36 h. b Substrate specific activity of NE 0.33 μg/mL with and without CSC (5–40 mg/mL) . Mucin concentration of the native control was set to 100 %