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. 2015 Jul 14;13:225. doi: 10.1186/s12967-015-0583-0

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© Ghonim et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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WT or PARP-1^−/− mice were subjected to OVA sensitization followed by a single or triple challenge (Multiple) or left unchallenged. WT mice were administered i.p. 1 mg/kg, 5 or 10 mg/kg of olaparib or saline 30 min after each challenge. Mice were sacrificed 48 h later and lungs were subjected to BAL. Assessment of BALF from the different groups for Th2 cytokines eotaxin, IL-4, IL-5, IL-6, IL-13, or M-CSF (a), IL-2 (b) or INF-γ (c). Data are means ± SD of values from at least six mice per group. Asterisk difference from control unchallenged mice, p < 0.01; hash difference from OVA-challenged mice; p < 0.01.