Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Time to healing
[26] RCT	47 people with partial-thickness burns (burn sites of individual randomised to either PVP-I hydrogel or silver sulfadiazine cream)	Mean time to wound closure 9.9 days with PVP-I hydrogel 11.9 days with silver sulfadiazine cream	P = 0.015 RCT not blinded because of characteristic colour of PVP-I hydrogel	Effect size not calculated	PVP-I hydrogel
Number of people healed
[11] Systematic review	80 people with second-degree burns Data from 1 RCT	Number of people healed day 6 6/40 (15%) with iconic hydrogel dressing 4/40 (10%) with silver sulfadiazine cream	RR 1.50 95%CI 0.46 to 4.91 P = 0.50 The study[25] had unclear blinding		Not significant
[11] Systematic review	80 people with second-degree burns Data from 1 RCT	Number of people healed day 9 20/40 (50%) with iconic hydrogel dressing 10/40 (10%) with silver sulfadiazine cream	RR 2.00 95%CI 1.08 to 3.72 P = 0.028 The study[25] had unclear blinding	Small effect size	iconic hydrogel dressing
[11] Systematic review	80 people with second-degree burns Data from 1 RCT	Number of people healed day 12 32/40 (80%) with iconic hydrogel dressing 19/40 (48%) with silver sulfadiazine cream	RR 1.68 95%CI 1.17 to 2.42 P = 0.0046 The study[25] had unclear blinding	Small effect size	iconic hydrogel dressing
[11] Systematic review	80 people with second-degree burns Data from 1 RCT	Number of people healed day 15 36/40 (90%) with iconic hydrogel dressing 31/40 (78%) with silver sulfadiazine cream	RR 1.16 95%CI 0.95 to 1.41 P = 0.14 The study[25] had unclear blinding		Not significant
Wound infection
[11] Systematic review	80 people with second-degree burns Data from 1 RCT	Infection with Pseudomonas aeruginosa requiring antibiotic therapy 0/40 (0%) with iconic hydrogel dressing 1/40 (3%) with silver sulfadiazine cream	RR 0.33 95% CI 0.01 to 7.95 P = 0.50		Not significant
Anti-infective efficacy (clinician-rated)
[26] RCT	47 people with partial-thickness burns (burn sites of individual randomised to either PVP-I hydrogel or silver sulfadiazine cream)	Anti-infective efficacy (rated as 'excellent' by clinician) 54% with PVP-I hydrogel 26.1% with silver sulfadiazine cream Absolute numbers not reported	Significance not assessed RCT not blinded because of characteristic colour of PVP-I hydrogel
[26] RCT	47 people with partial-thickness burns (burn sites of individual randomised to either PVP-I hydrogel or silver sulfadiazine cream)	Anti-infective efficacy (rated as 'good' by clinician) 43.5% with PVP-I hydrogel 67.4% with silver sulfadiazine cream Absolute numbers not reported	Significance not assessed RCT not blinded because of characteristic colour of PVP-I hydrogel
Cosmetic result (clinician-rated)
[26] RCT	47 people with partial-thickness burns (burn sites of individual randomised to either PVP-I hydrogel or silver sulfadiazine cream)	Cosmetic items (smoothness, elasticity, and appearance; rated as 'excellent' on clinician global assessment scale) 37% with PVP-I hydrogel 13% with silver sulfadiazine cream Absolute numbers not reported	Significance not assessed RCT not blinded because of characteristic colour of PVP-I hydrogel