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. 2015 Jul 15;26(14):2664–2672. doi: 10.1091/mbc.E14-11-1564

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© 2015 Cavolo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — MB inhibits retrograde but not anterograde DCV transport in the nerve terminal. (A) FRAP shows that nerve terminal anterograde DCV transport is maintained in MB. ANF-GFP images from the intact neuromuscular junction are oriented with the most distal bouton at the top. Scale bar, 3 μm. (B) SPAIM shows that retrograde transport out of the most distal bouton (at top of images) is blocked by MB. Scale bar, 3 μm. (C) Quantification from time-lapse experiments of anterograde DCV flux in the terminal and retrograde DCV flux out of the most distal bouton in controls (Con, open bars, n = 8), MB (black bars, n = 5), and LatA (blue bars, n = 4). **p < 0.01. (D) Lifeact-Ruby in terminal before and after treatment with LatA. Scale bar, 5 μm. ANF-GFP indicates the presence of DCVs.