TABLE 1:
DCV axonal transport parameters in hippocampal neurons.
| Traffic values | ||
|---|---|---|
| Anterograde | Retrograde | |
| Flux (min–1) | ||
| Control | 4.54 ± 0.58 | 3.35 ± 0.34 |
| Mycalolide B | 5.72 ± 0.82 | 0.07 ± 0.03*** |
| Latrunculin A | 4.88 ± 0.56 | 5.17 ± 0.62** |
| Velocity (μm/s) | ||
| Control | 1.37 ± 0.06 | 1.42 ± 0.06 |
| Mycalolide B | 1.32 ± 0.09 | 0.35 ± 0.13*** |
| Latrunculin A | 1.26 ± 0.03 | 1.36 ± 0.05 |
| Run length (μm) | ||
| Control | 6.41 ± 0.46 | 5.77 ± 0.28 |
| Mycalolide B | 10.19 ± 0.88*** | 1.81 ± 0.81*** |
| Latrunculin A | 5.56 ± 0.34 | 5.74 ± 0.35 |
Control (n = 40 kymographs, 40 cells, 2414 DCVs); mycalolide B (n = 22 kymographs, 22 cells, 633 DCVs); latrunculin A (n = 23 kymographs, 23 cells, 2089 DCVs).
**p < 0.01, when compared with control (from each column).
***p < 0.001, when compared with control (from each column).