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. 2015 Jul 15;26(14):2698–2711. doi: 10.1091/mbc.E14-09-1378

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© 2015 Hellesøy and Lorens. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — MAP kinase signaling is required for early capillary-like network formation. Cocultures of HUVECs with PaSMCs were treated with the MEK1 inhibitor PD-98059 (10 μM), the MEK1/2 inhibitor U0126 (10 μM), and the Akt inhibitor AktVIII (1 μM). Inhibitors were added at the indicated time points from days 0–5, and cultures were imaged for network quantification at day 5 or 6. PD 98059 and U0126 had a significant inhibitory effect when added at all time points. AktVIII addition was only assessed at days 0, 1, and 3. AktVIII did not affect network formation at any time point. Asterisk indicates significant differences from control (set to 100%). *p < 0.05, min n = 5, max n = 10.