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. 2015 Jul 15;26(14):2698–2711. doi: 10.1091/mbc.E14-09-1378

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© 2015 Hellesøy and Lorens. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Constitutive activation of PI3K-Akt and MAP kinase signaling pathways interferes with capillary-like network formation. (A) HUVECs expressing B-Raf V600E, myrAkt2, myrAkt3, PI3CA E545K, and myrPI3CA were cocultured and imaged after 5 d with fluorescence microscopy. (B) Quantification of network formation showed that B-Raf V600E- and myrAkt2-expressing HUVECs formed networks with significantly shorter tube total length than control, whereas networks formed by PI3CA E545K–expressing HUVECs had a significantly higher tube total length than controls. (C) The relative number of branch points in networks formed by all mutants except B-Raf V600E–expressing HUVECs was significantly less than in networks formed by control cells. Asterisk indicates statistically significant difference from control (set to 100%). *p < 0.01, min n = 20, max n = 29.