TABLE II. Genotoxicity, mutagenicity and mutagenic potency slope of nitroimidazoles 13, 16, 17 and 18.

Compound	Genotoxicity	Ames test (MI > 2) - Mutagenicity			Mutagenic potency slope (revertants/µg)
	1,562 µM	250 µM	1,250 µM	2,500 µM	TA97	TA98	TA100	TA102	TA1535
13	1 (300 TAU)	-	TA100	TA100	0.30 ± 0.22	NA	8.98 ± 0.71	NA	NA
16	0 (10 TAU)	-	TA100	TA100	NA	NA	6.60 ± 0.63	NA	NA
17	3 (411 TAU)	TA100	TA100	TA98, TA100	NA	0.55 ± 0.08	41.70 ± 3.71	2.51 ± 0.44	NA
18	0 (32 TAU)	-	TA100	TA98, TA100, TA102, TA1535	2.13 ± 0.14	0.69 ± 0.05	8.18 ± 0.15	NA	0.51 ± 0.07

MI: mutagenicity inde; NA: not applicable; TAU: total arbitrary units for the positive control, methyl methane-sulfonate value was 454.3 ± 9.2.