TABLE I. Mean pharmacokinetic parameters of isoniazid for the test formulation.
| Test |
|||||
|---|---|---|---|---|---|
| Cmax | AUC0-T | AUCinf | T1/2 | Tmax | |
| Mean | 4.619.77 | 12.425.53 | 13.375.63 | 2.54 | 0.75 |
| SD | 2.151.52 | 6.177.13 | 6.788.75 | 1.01 | 0.42 |
| CV | 0.47 | 0.50 | 0.51 | 0.40 | 0.56 |
| Minimum | 1.632.74 | 3.554.16 | 3.734.03 | 1.03 | 0.33 |
| Maximum | 10.820.88 | 26.327.94 | 27.856.54 | 4.26 | 2.00 |
AUC0-T: time zero to the last measurable concentration “time t”; AUCinf: area under the plasma concentration vs. time curve from zero to infinity; Cmax: maximum concentration of drug observed in plasma; CV: coefficient of variation; SD: standard deviation; T1/2: time it took the plasma concentration to reduce to 50% during the elimination phase; Tmax: time required to reach maximum concentration of drug in plasma.