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. 2015 Jul 7;6:7499. doi: 10.1038/ncomms8499

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In WT cells SUMOylated XPC is ubiquitylated by RNF111, promoting its release from damaged DNA. This RNF111-mediated XPC release facilitates XPG and ERCC1/XPF recruitment, thereby enabling an efficient NER reaction. In RNF111^−/− cells, where XPC is not modified by RNF111-dependent K63 ubiquitin chains, XPC remains more stably associated with the preincision NER complex. This interferes with proper loading of XPG, thereby inhibiting the NER reaction. Branched ‘Ub' represents K48-linked Ub chains, linear ‘Ub' represents K63-linked Ub chains; ‘S' represents SUMOylation; ‘1' and ‘2' represent DDB1 and DDB2, respectively.