Table 2. Characteristic measures of the dry-eye syndrome after three months treatment with Conheal.

	Month 3*		Comparison Month 3 vs Month 0				Comparison Month 3 vs Month 1
	Mean±SD		Shift parameter** and 95% CI		P value***		Shift parameter** and 95% CI		P value***
	right	left	right	left	right	left	right	left	right	left
LIPCOF degree	1.4±0.6	1.4±0.7	-2.0(-2.0 to -1.0)	-1.0(-2.0 to -1.0)	<0.001	<0.001	0.0(-1.0 to 0.0)	0.0(0.0 to 0.0)	0.035	0.312
TFBUT value	5.9±2.3	5.7±1.8	1.1(0.2 to 2.0)	0.9(0.3 to 1.5)	0.020	0.004	0.5(-0.3 to 1.3)	-0.0(-0.7 to 0.6)	0.191	0.953
Oxford grade	0.3±0.4	0.2±0.4	-1.0(-1.0 to -1.0)	-1.0(-1.0 to -1.0)	<0.001	<0.001	0.0(-1.0 to 0.0)	0.0(-1.0 to 0.0)	0.016	0.039
OSDI Score	15.6±16.7		-13.1(-25.0 to -8.3)		<0.001		-2.4(-5.7 to 0.0)		0.012

*LIPCOF degrees, TFBUT values, Oxford Scheme grades and OSDI scores were measured, and statistical analysis was performed as described in Methods. For Month 0 and Month 1 values, see Table 1.

**This column contains the median difference and its nonparametric CI for LIPCOF, Oxford and OSDI (Corresponding to the Wilcoxon Signed Rank test), whereas it contains the mean difference and 95% CI based on the t-distribution for TFBUT

***P-value of the Wilcoxon Signed Rank Test for LIPCOF, Oxford and OSDI, and P-value of the paired t-test for TFBUT (two-sided). Gray boxes represent the non-significant changes.