Figure 5.

Histology (H&E staining; magnification, ×100) of colonic samples taken from mice receiving either water (control), DSS, DSS + 0.5 mg rhA-IV, or DSS + 0.25 mg rhA-IV. Compared with that of control animals (A), colon of DSS-treated mice (B) shows complete destruction of epithelial architecture (arrowheads), with nearly complete loss of crypts, loss of epithelial integrity, edema (asterisk), and intense cellular inflammation in all layers (arrows). Treatment with 0.25 mg rhA-IV attenuated morphological damage but showed mild cellular infiltrate (D, arrow), whereas epithelial architecture was preserved in animals receiving the higher dose of 0.5 mg rhA-IV (C).