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. 2015 Jun 22;47(2):719–727. doi: 10.3892/ijo.2015.3060

Figure 6.

Figure 6

The BM-MSCs pre-treated NFs promote human PCa tumor growth and PCa cell invasion. (A) CWR22Rv1 cells, either alone or together with untreated or BM-MSCs 7-day pre-treated pshTERT cells were orthotopically injected into nude mice. Mouse group 1, CWR22Rv1 alone; group 2, CWR22Rv1 cells + pshTERT cells (media treated, control); group 3, CWR22R1 + pshTERT cells (pre-treated with hBM-MSCs for 7 days). For groups 2 and 3, the mixtures of CWR22Rv1 and pshTERT cells in a ratio of 5:1 were used in injection. After 6 weeks, mice were sacrificed and tumor weight was analyzed. Quantitation is shown on the right. *p<0.05. (B) Images of the invasion ability of LNCaP cells co-cultured with pshTERT or human BM-MSCs treated pshTERT cells. (C) Images of the invasion ability of C4-2 cells co-cultured with pshTERT or human BM-MSCs treated pshTERT cells.