Table 3. Univariate Cox proportional hazard models.
| Endpoint | Factor | Comparison | Hazard Ratio | 95% LCL | 95% UCL | P-value | # Event | # Censored | Total # Patients |
|---|---|---|---|---|---|---|---|---|---|
| RFS | ERG | Neg vs. Pos | 1.23 | 1.01 | 1.49 | 0.04 | 435 | 519 | 954 |
| SPINK1 | Neg vs. Pos | 3.32 | 1.48 | 7.42 | 0.004 | 438 | 525 | 963 | |
| ERG/SPINK1 | Neg vs. Pos | 1.33 | 1.1 | 1.61 | 0.003 | 435 | 519 | 954 | |
| Margin | Pos vs. Neg | 2.03 | 1.66 | 2.47 | < .0001 | 395 | 493 | 888 | |
| Stage | III/IV vs. I/II | 2.4 | 1.96 | 2.94 | < .0001 | 385 | 477 | 862 | |
| SVinv | No vs. Yes | 0.28 | 0.21 | 0.38 | < .0001 | 470 | 583 | 1053 | |
| ECE | No vs. Yes | 0.5 | 0.41 | 0.61 | < .0001 | 474 | 584 | 1058 | |
| Gleason | 3+4 vs. < = 6 | 1.58 | 1.27 | 1.98 | 0.0001 | 470 | 587 | 1057 | |
| 4+3 vs. < = 6 | 2.7 | 2.07 | 3.53 | < .0001 | |||||
| 8–10 vs. < = 6 | 2.62 | 1.96 | 3.52 | < .0001 | |||||
| Age | 1 unit increase | 1.01 | 0.99 | 1.02 | 0.43 | 459 | 502 | 961 | |
| Log(pre-op PSA) | 1 unit increase | 1.96 | 1.69 | 2.27 | < .0001 | 431 | 510 | 941 | |
| DSS | ERG | Neg vs. Pos | 1.16 | 0.65 | 2.07 | 0.61 | 49 | 899 | 948 |
| SPINK1 | Neg vs. Pos | NA | NA | NA | 0.99 | 50 | 907 | 957 | |
| ERG/SPINK1 | Neg vs. Pos | 1.32 | 0.74 | 2.35 | 0.35 | 49 | 899 | 948 | |
| Margin | Pos vs. Neg | 2.44 | 1.27 | 4.69 | 0.0073 | 37 | 847 | 884 | |
| Stage | III/IV vs. I/II | 6.7 | 3.13 | 14.33 | < .0001 | 35 | 821 | 856 | |
| SVinv | No vs. Yes | 0.29 | 0.15 | 0.57 | 0.0004 | 54 | 994 | 1048 | |
| ECE | No vs. Yes | 0.39 | 0.22 | 0.67 | 0.0007 | 52 | 1000 | 1052 | |
| Gleason | 3+4 vs. < = 6 | 2.55 | 1.19 | 5.47 | 0.02 | 53 | 998 | 1051 | |
| 4+3 vs. < = 6 | 3.56 | 1.44 | 8.82 | 0.006 | |||||
| 8–10 vs. < = 6 | 6.88 | 3.05 | 15.56 | < .0001 | |||||
| Age | 1 unit increase | 1.02 | 0.98 | 1.06 | 0.3 | 53 | 902 | 955 | |
| Log(pre-op PSA) | 1 unit increase | 2.12 | 1.49 | 3.02 | < .0001 | 47 | 888 | 935 | |
| OS | ERG | Neg vs. Pos | 0.72 | 0.41 | 1.26 | 0.25 | 49 | 893 | 942 |
| SPINK1 | Neg vs. Pos | 0.6 | 0.19 | 1.93 | 0.39 | 49 | 901 | 950 | |
| ERG/SPINK1 | Neg vs. Pos | 0.63 | 0.36 | 1.11 | 0.11 | 49 | 893 | 942 | |
| Margin | Pos vs. Neg | 1.67 | 0.99 | 2.83 | 0.06 | 56 | 823 | 879 | |
| Stage | III/IV vs. I/II | 2 | 1.19 | 3.38 | 0.01 | 57 | 792 | 849 | |
| SVinv | No vs. Yes | 0.4 | 0.19 | 0.85 | 0.02 | 57 | 984 | 1041 | |
| ECinv | No vs. Yes | 0.48 | 0.28 | 0.81 | 0.01 | 56 | 989 | 1045 | |
| Gleason | 3+4 vs. < = 6 | 0.93 | 0.47 | 1.84 | 0.83 | 58 | 986 | 1044 | |
| 4+3 vs. < = 6 | 1.27 | 0.51 | 3.17 | 0.61 | |||||
| 8–10 vs. < = 6 | 4.14 | 2.18 | 7.89 | < .0001 | |||||
| Age | 1 unit increase | 1.07 | 1.03 | 1.11 | 0.0011 | 58 | 890 | 948 | |
| Log(pre-op PSA) | 1 unit increase | 1.65 | 1.11 | 2.44 | 0.01 | 38 | 890 | 928 |
LCL = Lower Confidence Limit, UCL = Upper Confidence Limit, RFS = Recurrence Free Survival, DSS = Disease Specific Survival, OS = Overall Survival