Table 4. Multivariate Cox proportional hazard models.

Endpoint	Factor	Comparison	Hazard Ratio	95% LCL	95% UCL	P-value
RFS (N = 674,E = 306)	SPINK1	Neg vs. Pos	2.84	1.17	6.90	0.02
	Margin	Pos vs. Neg	1.78	1.41	2.24	<0.0001
	SVinv	Yes vs. No	2.37	1.63	3.43	<0.0001
	Gleason	3+4 vs. < = 6	1.46	1.10	1.95	0.009
		4+3 vs. < = 6	2.09	1.49	2.93	< .0.0001
		8–10 vs. < = 6	1.82	1.26	2.65	0.002
	Log(pre-op PSA)	1 unit increase	1.56	1.31	1.86	< .0.0001
DSS (N = 929,E = 46)	Gleason	3+4 vs. < = 6	2.69	1.11	6.49	0.03
		4+3 vs. < = 6	3.67	1.34	10.07	0.01
		8–10 vs. < = 6	6.27	2.41	16.31	0.0002
	Log(pre-op PSA)	1 unit increase	1.80	1.23	2.64	0.003
OS (N = 940, E = 58)	Gleason	3+4 vs. < = 6	0.88	0.44	1.73	0.71
		4+3 vs. < = 6	1.11	0.44	2.77	0.82
		8–10 vs. < = 6	3.25	1.70	6.24	0.0004
	Age	1 unit increase	1.06	1.02	1.10	0.006

N = total number of patients, E = number of patients with events

LCL = Lower Confidence Limit, UCL = Upper Confidence Limit