Table 2. Crude and multi-adjusted odds ratios and 95% CIs of the relation of diabetes and prediabetes to HHEX_23 and IDE_9 in the Kungsholmen Project and SNAC-K.
| Genotype/Phenotype | Kungsholmen Project | SNAC-K | ||||
|---|---|---|---|---|---|---|
| n a | Diabetes/Prediabetes | n a | Diabetes/Prediabetes | |||
| Crude OR (95% CI) | Adjusted OR (95% CI) b | Crude OR (95% CI) | Adjusted OR (95% CI) b | |||
| HHEX_23 genotype | ||||||
| GG | 26/224 | 1.00 (Ref.) | 1.00 (Ref.) | 167/335 | 1.00 (Ref.) | 1.00 (Ref.) |
| AG | 50/408 | 2.38 (1.04–5.56) | 2.36 (1.04–5.35) | 360/664 | 2.18 (1.21–3.26) | 2.13 (1.16–3.97) |
| AA | 38/224 | 2.47 (1.11–5.47) | 2.41 (1.01–5.78) | 198/336 | 2.41 (1.34–3.84) | 2.36 (1.28–3.96) |
| HHEX_23 phenotype | ||||||
| G | 102/856 | 0.80 (0.45–1.42) | 0.78 (0.43–1.42) | 694/1,334 | 0.70 (0.39–1.29) | 0.69 (0.40–1.37) |
| A | 126/856 | 2.43 (1.13–5.22) | 2.28 (1.05–5.96) | 756/1,336 | 2.22 (1.08–4.89) | 2.04 (1.03–4.12) |
| A allele | 982 | 1.35 (0.97–1.88) c | 2,092 | 1.16 (0.97–1.39) d | ||
| IDE_9 genotype | ||||||
| TT | 74/600 | 1.00 (Ref.) | 1.00 (Ref.) | 483/925 | 1.00 (Ref.) | 1.00 (Ref.) |
| TC | 37/235 | 1.07 (0.65–1.77) | 1.08 (0.65–1.87) | 214/372 | 1.23 (0.71–2.63) | 1.18 (0.66–3.03) |
| CC | 3/21 | 0.87 (0.66–2.56) | 0.84 (0.56–2.66) | 28/38 | 0.85 (0.77–3.11) | 0.78 (0.70–3.21) |
| IDE_9 phenotype | ||||||
| T | 185/1,435 | 0.81 (0.46–1.44) | 0.79 (0.463–1.43) | 1,180/2,222 | 0.60 (0.53–1.65) | 0.63 (0.44–1.54) |
| C | 43/277 | 1.43 (0.93–5.22) | 1.28 (0.85–4.96) | 270/448 | 0.79 (0.66–3.29) | 0.78 (0.71–4.02) |
| C allele | 320 | 0.96 (0.89–1.94) | 718 | 0.74 (0.69–1.38) | ||
aNumber of participants with/without diabetes.
bAdjusted for age, sex, education, stroke, heart disease, SBP, DBP, BMI, and APOE ε4 status.
c p = 0.066.
d p = 0.065.