Table 2.
Clinical Scores After Adjusting for Age, Sex, Education, Frequency of Plaques and Tangles
| Test | Participants Who Had AD Without Lewy Bodies
|
Participants Who Had AD With Lewy Bodies
|
P Value | ||
|---|---|---|---|---|---|
| Mean (SE) Score | 95% CI | Mean (SE) Score | 95% CI | ||
| Total sample (n = 531) | |||||
|
| |||||
| NPI-Q (n = 493) | 5.49 (1.39) | 2.76–8.23 | 6.59 (1.44) | 3.75–9.42 | .04 |
|
| |||||
| UPDRS motor score (n = 531) | 0.54 (0.18) | 0.19–0.88 | 0.81 (0.18) | 0.45–1.17 | <.001 |
|
| |||||
| CDR-SB (n = 531) | 9.17 (1.21) | 6.80–11.54 | 9.78 (1.25) | 7.33–12.23 | .16 |
|
| |||||
| Subanalyses of sample of participants with CDR 0, 0.5, or 1 (n = 160) | |||||
|
| |||||
| GDS (n = 147) | 5.12 (1.31) | 2.54–7.71 | 6.91 (1.41) | 4.13–9.69 | <.001 |
|
| |||||
| NPI-Q (n = 149) | 3.73 (1.87) | 0.04–7.42 | 4.35 (2.00) | 0.40–8.30 | .42 |
|
| |||||
| MMSE (n = 150) | 25.30 (2.38) | 20.62–30.00 | 24.29 (2.54) | 19.30–29.32 | .27 |
|
| |||||
| UPDRS (n = 160) | 0.26 (0.19) | −0.13 to 0.64 | 0.63 (0.21) | 0.22–1.04 | <.001 |
|
| |||||
| CDR-SB (n = 160) | 3.25 (1.10) | 1.08–5.43 | 3.82 (1.18) | 1.48–6.16 | .21 |
|
| |||||
| Logical memory (n = 148) | 7.14 (1.80) | 3.59–10.69 | 7.05 (1.94) | 3.22–10.88 | .91 |
|
| |||||
| Long-term memory units (n = 146) | 5.87 (1.90) | 2.11–9.64 | 6.50 (2.06) | 2.44–10.57 | .44 |
|
| |||||
| Boston Naming Test (n = 140) | 22.55 (2.94) | 16.74–28.37 | 22.17 (3.16) | 15.92–28.42 | .74 |
|
| |||||
| Animal fluency (n = 151) | 13.78 (2.37) | 9.09–18.50 | 13.20 (2.57) | 8.16–18.32 | .59 |
Abbreviations: AD, Alzheimer disease; CDR-SB, Clinical Dementia Rating sum of boxes; GDS, Geriatric Depression Scale; MMSE, Mini-Mental State Examination; NPI-Q, Neuropsychiatric Inventory Questionnaire; UPDRS, Unified Parkinson Disease Rating Scale.