Table 3.
Clinical Scores After Adjusting for Age, Sex, Education, Frequency of Plaques and Tangles, and APOE ε4 Status
| Test | Participants Who Had AD Without Lewy Bodies
|
Participants Who Had AD With Lewy Bodies
|
P Value | ||
|---|---|---|---|---|---|
| Mean (SE) Score | 95% CI | Mean (SE) Score | 95% CI | ||
| Total sample (n = 531) | |||||
|
| |||||
| NPI-Q (n = 351) | 5.95 (1.5) | 3.0–8.9 | 6.78 (1.59) | 3.65–9.90 | .18 |
|
| |||||
| UPDRS motor score (n = 380) | 0.42 (0.19) | 0.04–0.80 | 0.60 (0.20) | 0.20–0.99 | .02 |
|
| |||||
| CDR-SB (n = 380) | 8.47 (1.26) | 6.00–10.94 | 8.38 (1.33) | 5.77–10.99 | .86 |
|
| |||||
| Subanalyses of sample of participants with CDR 0, 0.5, or 1 (n = 160) | |||||
|
| |||||
| GDS (n = 147) | 5.21 (1.50) | 2.23–8.18 | 7.02 (1.64) | 3.76–10.30 | .02 |
|
| |||||
| NPI-Q (n = 149) | 3.38 (1.71) | −0.01 to 6.77 | 3.09 (1.87) | −0.62 to 6.80 | .73 |
|
| |||||
| MMSE (n = 150) | 24.74 (2.49) | 19.81–29.70 | 24.49 (2.70) | 19.14–29.84 | .82 |
|
| |||||
| UPDRS (n = 160) | 0.33 (0.18) | −0.02 to 0.68 | 0.64 (0.19) | 0.25–1.02 | <.001 |
|
| |||||
| CDR-SB (n = 160) | 3.62 (1.16) | 1.32–5.93 | 3.62 (1.27) | 1.10–6.15 | >.99 |
|
| |||||
| Logical memory (n = 148) | 6.72 (1.96) | 2.82–10.61 | 7.53 (2.15) | 3.25–11.81 | .41 |
|
| |||||
| Long-term memory units (n = 146) | 5.46 (2.11) | 1.26–9.66 | 7.09 (2.33) | 2.46–11.70 | .13 |
|
| |||||
| Boston Naming Test (n = 140) | 23.85 (2.87) | 18.14–29.56 | 22.76 (3.16) | 16.48–29.04 | .42 |
|
| |||||
| Animal fluency (n = 151) | 13.66 (2.53) | 8.63–18.68 | 13.44 (2.79) | 7.89–18.98 | .86 |
Abbreviations: AD, Alzheimer disease; CDR-SB, Clinical Dementia Rating sum of boxes; GDS, Geriatric Depression Scale; MMSE, Mini-Mental State Examination; NPI-Q, Neuropsychiatric Inventory Questionnaire; UPDRS, Unified Parkinson Disease Rating Scale.