Table 4.
Likelihood of Having More Severe Symptoms on Each NPI-Q Item After Adjusting for Age, Sex, Education, and Frequency of Plaques and Tanglesa
| NPI-Q Item | None vs Any Symptoms
|
Mild vs Severe
|
||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Delusion | 2.286 (1.496–3.492) | <.001 | 2.133 (1.243–3.661) | .01 |
|
| ||||
| Hallucination | 2.849 (1.791–4.534) | <.001 | 2.188 (1.196–4.004) | .01 |
|
| ||||
| Agitation | 1.186 (0.803–1.753) | .39 | 0.852 (0.545–1.332) | .48 |
|
| ||||
| Depression | 0.749 (0.510–1.100) | .14 | 1.033 (0.636–1.680) | .90 |
|
| ||||
| Anxiety | 1.421 (0.964–2.094) | .08 | 1.309 (0.835–2.054) | .24 |
|
| ||||
| Euphoria | 0.679 (0.322–1.431) | 1.43 | 0.764 (0.242–2.410) | .65 |
|
| ||||
| Apathy | 1.146 (0.782–1.680) | .49 | 1.370 (0.927–2.025) | .11 |
|
| ||||
| Disinhibition | 1.267 (0.821–1.955) | .29 | 0.925 (0.512–1.672) | .80 |
|
| ||||
| Irritability | 0.898 (0.610–1.323) | .59 | 1.157 (0.722–1.855) | .54 |
|
| ||||
| Aberrant motor behavior | 1.56 (1.030–2.363) | .04 | 1.799 (1.121–2.887) | .02 |
|
| ||||
| Sleep behavior problems | 1.291 (0.881–1.893) | .19 | 1.552 (1.011–2.383) | .045 |
|
| ||||
| Appetite and eating | 0.966 (0.655–1.426) | .86 | 1.254 (0.794–1.980) | .33 |
Abbreviations: OR, odds ratio; NPI-Q, Neuropsychiatric Inventory Questionnaire.
a
The severity of each symptom was evaluated in 2 ways: one looked at no symptoms vs any symptoms, and the other looked at mild (none to mild) vs severe (moderate to severe) symptoms.