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Testosterone or estrogen replacement prevents gonadectomy-induced anhedonia. While gonadectomized rats receiving a placebo pellet (GDX) have a sucrose preference lower than sham-operated animals, gonadectomized rats with testosterone (GDX+T) or estrogen (GDX+E) replacement exhibit similar levels compared to sham-operated animals (Sham). * p < 0.05 vs. SHAM, GDX+T and GDX+E, Fisher’s PLSD post-hoc test.
