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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Biol Psychiatry. 2015 Jan 14;78(4):259–269. doi: 10.1016/j.biopsych.2014.12.024

Figure 4.

Figure 4

Fadrozole effectively inhibits local conversion of testosterone to estradiol in the dorsal hippocampus. (4A) Representation of the infusion sites (black circles) on The Rat Brain Atlas (Paxinos and Watson), ranging from −3.60 mm to −4.52 mm from Bregma. (4B) Significantly elevated levels of testosterone were measured in the dorsal hippocampus of testosterone-supplemented male rats receiving fadrozole infusions compared to those receiving saline infusions. Conversely, low to undetectable levels of testosterone were observed in placebo-treated rats, regardless of local aromatase inhibition.