Table 2.

Diaphyseal Bone Parameters Measured by MicroCT for Strain-Matched (1200µe) Loading and Unloading Studies

Diaphyseal VOI	Parameters	Loading Study				Unloading Study
		WT		Sost−/−		WT		Sost−/−
		Control	Loaded	Control	Loaded	Control	Unloaded	Control	Unloaded
37% Cortical	BV (mm3)	0.55 ± 0.03	0.64 ± 0.03a	0.74 ± 0.05	0.88 ± 0.05a	0.50 ± 0.02	0.47 ± 0.02a	0.68 ± 0.06	0.68 ± 0.06
	Ct.Th (mm)	0.26 ± 0.01	0.30 ± 0.01a	0.34 ± 0.00	0.39 ± 0.01a	0.24 ± 0.01	0.22 ± 0.00a	0.31 ± 0.01	0.31 ± 0.02
	Ps (mm)	5.84 ± 0.26	6.14 ± 0.25a	6.06 ± 0.29	6.34 ± 0.29a	5.75 ± 0.19	5.68 ± 0.27	5.94 ± 0.33	5.95 ± 0.26
	Ec (mm)	3.66 ± 0.14	3.74 ± 0.22	3.51 ± 0.26	3.69 ± 0.45	3.85 ± 0.23	4.11 ± 0.27b	3.95 ± 0.42	3.96 ± 0.30
	MMI(polar) (mm4)	0.48 ± 0.06	0.60 ± 0.07a	0.67 ± 0.10	0.87 ± 0.11a	0.42 ± 0.03	0.41 ± 0.06	0.61 ± 0.10	0.62 ± 0.09
	TMD (g/cm3)	1.47 ± 0.03	1.48 ± 0.04	1.56 ± 0.03	1.59 ± 0.02a	1.39 ± 0.04	1.39 ± 0.07	1.52 ± 0.03	1.52 ± 0.04
50% Cortical	BV (mm3)	0.41 ± 0.02	0.49 ± 0.03a	0.60 ± 0.04	0.68 ± 0.05a	0.38 ± 0.01	0.36 ± 0.02a	0.56 ± 0.03	0.55 ± 0.03
	Ct.Th (mm)	0.28 ± 0.00	0.32 ± 0.02a	0.37 ± 0.00	0.41 ± 0.01a	0.26 ± 0.00	0.24 ± 0.00a	0.36 ± 0.01	0.35 ± 0.01b
	Ps (mm)	4.10 ± 0.16	4.42 ± 0.17a	4.66 ± 0.25	4.85 ± 0.22b	4.13 ± 0.14	4.05 ± 0.17	4.48 ± 0.23	4.51 ± 0.24
	Ec (mm)	2.23 ± 0.12	2.31 ± 0.23	2.31 ± 0.36	2.29 ± 0.45	2.48 ± 0.19	2.50 ± 0.15	2.45 ± 0.33	2.35 ± 0.20
	MMI(polar) (mm4)	0.19 ± 0.03	0.25 ± 0.03a	0.31 ± 0.05	0.37 ± 0.06a	0.17 ± 0.02	0.17 ± 0.02	0.28 ± 0.04	0.28 ± 0.03
	TMD (g/cm3)	1.65 ± 0.03	1.64 ± 0.05	1.73 ± 0.04	1.74 ± 0.02	1.52 ± 0.05	1.53 ± 0.06	1.66 ± 0.04	1.67 ± 0.04
n		10	10	10	10	10	10	10	10

^ap < 0.01.

^bp < 0.05 compared to contralateral control.