Table 1.

Basic parameters

Parameter	Explanation	Value	Source
p_death_rest	non-T2DM mortality	age-specific	[27]
p_T2DM	age-specific incidence of T2DM	age-specific	[28]
p_Diagnosis_late	probability of clinical diagnosis with persisting complications	0.2	Assumption
p_Diagnose_early	probability of clinical diagnosis without complications or in the first year after development of complications	0.08	Assumption
p_OAD	probability of change of therapy to OAD-therapy	0.98	Assumption
p_Insulin	probability of change of therapy to OAD/insulin or mono-insulin	0.04	[29]
p_Insulin_Adherence	share of patients taking insulin in those requiring it	0.125	[30]
p_OAD_Adherence	share of patients taking OAD medication in those requiring it	0.125	[30]
p_stroke_death	stroke-related mortality	0.38136	[31]
p_MI_death	myocardial infarction-related mortality	0.7068	[31]
p_nephro	incidence diabetic nephropathy	0.01479	[32]
p_retino	incidence diabetic retinopathy	0.02124	[33]
p_neuro	incidence distal symmetric neuropathy	0.04658	[34]
p_Angina	incidence angina pectoris	0.00668	[31]
p_PVD	incidence PVD	0.00847	[35]
p_MI	incidence myocardial infarction	0.01735	[31]
p_stroke	incidence stroke	0.00529	[31]
p_heartfailure	incidence heart failure	0.00329	[31]
c_Diagnosis	unit cost FPG-test	1.00 USD	[36]
c_ambulatory	Annual cost outpatient treatment	2.66 USD	[36,37]
c_Laboratory	Annual cost laboratory exams	1.28 USD	[36,38]
c_OAD	Annual average cost for OAD medication	24.85 USD	[36,38,39]
c_Insulin	Annual average cost for insulin therapy (weighted mean for monotherapy and insulin-OAD-combined therapy)	114.26 USD	[36,38,39]
c_Hospital	Annual average cost for inpatient treatment	35.89 USD	[40]

*adjusted.